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However, biochemists speculate that there may have been some concurrent advantage of this mutation that caused it to persist and spread in the human lineage

Manta et al., 2019

One possible explanation is that, despite encoding the GGLG and YF motifs, the susceptibility to hyperoxidation for each of these 10 species may in fact be sufficiently low that AhpC-PRX1 inactivation does not occur

However, Eggers test detected a significant risk of publication bias in MCI brain GSH literature (bias [95%CI] = 11.28 [20.6, 1.95], p =0.03) and AD blood GSH literature (bias [95%CI] = 5.18 [9.96, 0.40], p =0.035)

[DOI] [PubMed] [Google Scholar] 14.Arning J, Dringen R, Schmidt M, Thiessen A, Stolte S, Matzke M, Bottin-Weber U, Caesar-Geertz B, Jastorff B, Ranke J

10.1016/j.ecoenv.2025.117964 138 YasudaM.TanakaY.RyuM.TsudaS.NakazawaT